ODCs

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2 OMIM references -
2 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 1

2 OMIM references -
2 associated genes
11 signs/symptoms

Hereditary combined deficiency of vitamin K-dependent clotting factors

Hemochromatosis type 2

GGCX	(UniProt - OMIM)		HAMP	(UniProt - OMIM)
VKORC1	(UniProt - OMIM)		HFE2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	VKORC1	(0.63)	HAMP

Citations in the biomedical literature:

Hereditary combined deficiency of vitamin K-dependent clotting factors		Hemochromatosis type 2
	Synonym(s): - Hereditary combined deficiency of factors II, VII, IX and X		Synonym(s): - Juvenile hemochromatosis

	Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare hepatic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: young adult Type of inheritance: autosomal recessive

	External references: 2 OMIM references - No MeSH references		External references: 2 OMIM references - 1 MeSH reference: C537247

Hemochromatosis type 2
	Very frequent - Autosomal recessive inheritance - Congenital hepatic fibrosis - Diabetes mellitus - Diffuse / generalised skin hyperpigmentation / melanoderma - Hyperferritinemia / iron overload - Late puberty / hypogonadism / hypogenitalism Frequent - Abnormal pigmentary skin changes / skin pigmentation anomalies - Articular / joint pain / arthralgia - Cardiomyopathy / hypertrophic / dilated Occasional - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets - Pancreatic failure / exocrine pancreas disease
Hereditary combined deficiency of vitamin K-dependent clotting factors
(no data available)